[Treatment] DNA

[Treatment] DNA

Gene therapy is integrated with normal genes into cells, correction and replacement genes that cause a method of treatment. Currently Broadly speaking, some will be transferred to patients with genetic material within cells to play a role in order to achieve purpose of treating disease, also referred to as gene therapy.

At present gene therapy, the method used can basically be divided into the following types:

1  DNA Correction

Correction DNA chain refers to the abnormal pathogenic DNA base rectify normal part be retained.

2. DNA replacement

DNA replacement is to use the normal DNA in vivo DNA through homologous recombination, in situ lesions replacement pathogenic DNA in the cell, the DNA within the cells fully restored to normal conditions.

3. Added DNA

DNA will be added to that purpose of DNA into cells or other cells lesion, removing abnormal DNA, but through DNA purpose of the non-site-specific integration, and expression of compensation to the function of DNA defects or to the original function has been strengthened. At present DNA treatment of multiple use of such methods. This method is added to the more dominant DNA for the treatment of recessive disease.

4. DNA inactivation

Early generally refers antisense oligonucleotide technology. It is a specific antisense RNA, including antisense RNA, antisense and ribozymes DNA into cells, the level of transcription and translation in blocking the abnormal expression of certain genes. In recent years have anti-gene strategy, peptide nucleic acid, DNA and RNA interference removed.

[DNA is the genetic material of all living organisms - the basis of

DNA (deoxyribonucleic acid) is a class of nucleic acid, containing elements for deoxyribose named.

Very large DNA molecules (molecular weight, at least in general over 1 million), the main component is deoxynucleotidyl adenine, guanine deoxynucleotidyl, cytosine and thymine deoxynucleotidyl deoxynucleotidyl. DNA exists in the nucleus, mitochondria and chloroplasts, can also exist in the free state of certain cell cytoplasm. Most of the known phage, some animal virus and a handful of plant viruses also contain DNA.

In addition to RNA (ribonucleic acid) and phage, DNA is the genetic material of all living organisms basis. The similarity between organisms paternity and inheritance of the so-called genetic information, stored in the DNA molecule. 1953, Danmushiwosen and Francis Crick describe the structure of DNA: the one-to-many mutual coiled chain nucleotide composition of the double helix. Thus, they are with the London Institute of Technology physicist Frederick countries Keweierjinshi shared the 1962 Nobel Prize in Physiology or Medicine.

[Obese gene]

Royal London Hospital scientists found that in obese body, there is a unique function of the gene, the gene of the three colleagues in the chromosome. As the obesity gene exists only in the body, therefore, the scientists called "obesity gene."

The study found that obese gene to the body to create a transport fat in the blood protein - "APO-D" gene. The gene more fat more fluent in blood circulation, the accumulation of fat in the more people will be obese. Below scientists conducted an interesting experiment: Let a portable mouse obese gene mating results and future generations of each roller melon circular slip become a meat ball, and did not allow a mouse obese gene mating, production of less fat mice, each very emaciated. Genetic scientists in accordance with this model, but also produce free of fat in 20 ~ 50% of the mice Feishou varying degrees. Further found that the obese gene and rodent genetic situation is somewhat different, are generational genetic. That is, people can observe, and to a considerable number of families, fat grandmother general obesity gene will not be passed to their children, but to her grandchildren were. The scientists also found that obesity-related genes more than one. For example, New York's Rockefeller University, a research team recently announced that they After eight years of long study, found a can control appetite and energy metabolism genes. It is reported that the gene can be sent to the brain to stop eating a signal to the brain's master timely weakened appetite, in order to avoid excess energy if the gene variation, the master will increase appetite, Tanzui eat, and eventually become a big fat. Further study revealed that the gene from the 4500 base composition, some of which can produce from 167 amino acid composition of proteins. If this protein synthesis normal, we will be able to stop eating the brain that signal if the encoded protein encoded amino acid composition of the first 105 amino acid residues of the unusual base, the signal to stop eating will malfunction, resulting in obesity.